Key to Nipah virus prevention and control: BNGG integrated solution

A recent global public health emergency alert has been issued regarding the spread of a highly pathogenic agent carried by fruit bats. This agent has a long incubation period and insidious transmission, and further spread could pose a significant public health risk. Currently, there is no effective vaccine; therefore, rapid and accurate early screening and dynamic monitoring are crucial for prevention and control.

In response to this public health protection need, BNCC has launched an integrated research solution combining quality inspection and quality control, including a Nipah virus N gene pseudovirus quality control product and a Nipah virus nucleic acid detection kit, providing technical support for early pathogen monitoring and warning.

Firstly, the standard reference system, the pseudovirus quality control product, targets the Nipah virus N gene to construct a pseudovirus structure. It contains no live virus components and can be safely operated in a standard laboratory environment. Through digital PCR and multi-laboratory calibration, it can completely simulate the entire pathogen nucleic acid detection process, providing crucial evidence for the accuracy and comparability of experimental results, and facilitating data traceability and standardized quality control.

The accompanying high-efficiency detection tool, the nucleic acid detection kit, is developed based on quantitative real-time PCR technology. It targets conserved pathogen sequences and features a specific detection system designed to effectively identify low-load samples. The pre-mixed single-tube system simplifies the operation process. After sample addition, it can be directly tested, with results output in approximately one hour. It is compatible with mainstream domestic and international fluorescence PCR instruments and suitable for rapid screening and continuous monitoring in various scenarios. In research and application scenarios, this solution can be used for early pathogen screening and source tracing studies, batch sample analysis and situation assessment in disease control and port inspections, and method validation, capability evaluation, and standardization in research institutions and third-party laboratories.

Faced with the challenges of public health emergencies, BNCC has consistently focused on pathogen detection and quality control, leveraging its advantages in sensitive detection and precise quality control to provide research-level technical support for prevention and control efforts, helping to build an efficient and reliable public health protection system.